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KMID : 0371320080750020084
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Journal of the Korean Surgical Society
2008 Volume.75 No. 2 p.84 ~ p.89
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Correlation between the Expression of Nuclear Factor-?B p65 Protein with the Expression of Nuclear Factor-?B p50 Protein and the Clinicopathologic Factors in Colorectal Cancer
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Kang Gi-Chang
Choi Young-Cheol
Kim Beom-Gyu
Cha Sung-Jae
Chang In-Taek
Park Sung-Il
Lee Tae-Jin
Choi Yoo-Shin
Park Jun-Seok
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Abstract
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Purpose: Nuclear Factor-?B p65 (NF-?B p65) and nuclear Factor-?B1 p50 (NF-?B p65) have been shown to play roles in cell proliferation, apoptosis, cytokine production and oncogenesis. This study was designed to investigate the expressions of NF-?B p65 and NF-?B p50 proteins in premalignant lesions and colorectal adenocarcinoma.
Methods: Paraffin sections of 20 normal mucosa specimens, 20 low grade tubular adenoma specimens, 20 high grade tubular adenoma specimens and 64 adenocarcinoma specimens were analyzed immunohistochemically for the expressions of NF-?B p65 and NF-?B p50 proteins.
Results: The expressions of NF-?B p65 and NF-?B p50 proteins were significantly higher in the adenocarcinoma tissue compared with that in the normal mucosa, the low grade tubular adenoma and the high grade tubular adenoma tissues. The frequency of a NF-?B p50 expression was higher in the poorly differentiated histologic grade specimens, in the presence of nodal metastasis and in the high stage specimens. There were significant correlations between the NF-?B p65 and NF-?B p50 proteins.
Conclusion: The expressions of NF-?B p65 and NF-?B p50 proteins may play a role in the pathogenesis of colorectal carcinoma. (J Korean Surg Soc 2008;75:84-89)
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KEYWORD
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NF-?B p65, NF-?B p50, Colorectal cancer
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